Papers
Research raises fresh questions on adverse impact of ‘long Covid’. Here’s why a vaccine-plus approach is needed
Today. Mar 2022
Clearing the air on Covid-19 transmission
The Straits Times. Feb 2022
Most primary olfactory neurons have individually neutral effects on behavior
Tayfun Tumkaya, Safwan Burhanudin, Asghar Khalilnezhad, James Stewart, Hyungwon Choi, Adam Claridge-Chang
eLife 2022. Data available at Zenodo.
China’s ‘zero Covid’ vs Singapore’s ‘living with it’: rapid low-cost testing could mean we don’t need to choose
South China Morning Post. Oct 2021
Contingent stimulus delivery assay for zebrafish reveals a role for CCSER1 in alcohol preference
Fatima Megala Nathan, Caroline Kibat, Tanisha Goel, James Stewart, Adam Claridge-Chang, Ajay S Mathuru
Addiction Biology 2022.
Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host
Benjamin Wong Wei Xiang, Wilfried A. A. Saron, James Charles Stewart, Arthur Hain, Varsha Walvekar, Dorothée Missé, Fréderic Thomas, R. Manjunatha Kini, Benjamin Roche, Adam Claridge-Chang, Ashley L. St John, Julien Pompon
PNAS 2022.
Characterization of seizure induction methods in Drosophila
Jurga Mituzaite, Rasmus Petersen, Adam Claridge-Chang, Richard A. Baines
eNeuro 2021.
A neural m6A/YTHDF pathway is required for learning and memory in Drosophila
Lijuan Kan, Stanislav Ott, Brian Joseph, Eun Sil Park, Crystal Dai, Ralph Kleiner, Adam Claridge-Chang, Eric C. Lai
Nature Communications 2021.
Neurons that function within an integrator to promote a persistent behavioral state in Drosophila
Yonil Jung, Ann Kennedy, Hui Chiu, Farhan Mohammad, Adam Claridge-Chang, David J. Anderson
Neuron 2020.
Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy
Holger Hengel et al. Nature Communications 2019.
Moving beyond P values: Data analysis with estimation plots
Joses Ho, Tayfun Tumkaya, Sameer Aryal, Hyungwon Choi, Adam Claridge-Chang
Nature Methods 2019. (bioRxiv 2018)
Learning a spatial task by trial and error in Drosophila
Ulrich Stern, Hemant Srivastava, Hsueh-Ling Chen, Farhan Mohammad, Adam Claridge-Chang, Chung-Hui Yang
Current Biology 2019.
Motor context coordinates visually guided walking in Drosophila
Tomás Cruz, Terufumi Fujiwara, Nélia Varela, Farhan Mohammad, Adam Claridge-Chang, M Eugenia Chiappe
bioRxiv. 2019.
Fully automated leg tracking of Drosophila neurodegeneration models reveals distinct conserved movement signatures
Shuang Wu, Kah Junn Tan, Lakshmi Narasimhan Govindarajan, James Charles Stewart, Lin Gu, Joses Wei Hao Ho, Malvika Katarya, Boon Hui Wong, Eng-King Tan, Daiqin Li, Adam Claridge-Chang, Camilo David Libedinsky, Li Cheng, Sherry Shiying Aw
PLOS Biology 2019. (bioRxiv 2018)
Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity
Anders Eriksson, Prachi Anand, Juliette Gorson, Corina Grijuc, Elina Hadelia, James Stewart, Mandë Holford, Adam Claridge-Chang
Scientific Reports. 2018.
A systematic review of Drosophila short-term-memory genetics: meta-analysis reveals robust reproducibility
Tayfun Tumkaya, Stanislav Ott, Adam Claridge-Chang
Neuroscience and Biobehavioral Reviews. 2018.
The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors
Joel Selkrig, Farhan Mohammad, Soon Hwee Ng, Jia Yi Chua, Tayfun Tumkaya, Joses Ho, Yin Ning Chiang, Dirk Rieger, Sven Pettersson, Charlotte Helfrich-Foerster, Joanne Yew, Adam Claridge-Chang
Scientific Reports. 2018.
A zinc-finger fusion protein refines Gal4-defined neural circuits
Shamprasad Varija Raghu, Farhan Mohammad, Jia Yi Chua, Claudia Barros, Joanne Lam, Mavis Loberas, Sadhna Sahani, Adam Claridge-Chang
Molecular Brain. 2018.
Optical inhibition of zebrafish behavior with anion channelrhodopsins
Gadisti Aisha Mohamed, Ruey-Kuang Cheng, Joses Ho, Seetha Krishnan, Farhan Mohammad, Adam Claridge-Chang and Suresh Jesuthasan.
BMC Biology. 2017
Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
Anders Eriksson, Marlena Raczkowska, Rapeechai Navawongse, Deepak Choudhury, James Stewart, Yi Ling Tang, Zhiping Wang, Adam Claridge-Chang.
Scientific Reports. 2017.
Optogenetic inhibition of behavior with anion channelrhodopsins
Farhan Mohammad, James Stewart, Stanislav Ott, Katarina Chlebikova, Jia Yi Chua, Tong-Wey Koh, Joses Ho, Adam Claridge-Chang.
Nature Methods. 2017. https://doi.org/10.1038/nmeth.4148
Lie-X: Depth image based articulated object pose estimation, tracking, and action recognition on Lie groups
Chi Xu, Lakshmi Narasimhan Govindarajan, Yu Zhang, James Stewart, Zoë Bichler, Suresh Jesuthasan, Adam Claridge-Chang, Ajay Sriram Mathuru, Wenlong Tang, Peixin Zhu, Li Cheng.
International Journal of Computer Vision. 2017.
Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses.
Farhan Mohammad, Joses Ho, Chun Lei Lim, Jia Hern Woo, Dennis Jun Jie Poon, Bhumika Lamba, Adam Claridge-Chang.
Neuroscience & Biobehavioral Reviews. 2016. doi:10.1016/j.neubiorev.2016.04.011
Ancient anxiety pathways influence Drosophila defense behaviors.
Farhan Mohammad, Sameer Aryal, Joses Ho, James Charles Stewart, Nurul Ayuni Norman, Teng Li Tan, Agnese Eisaka, Adam Claridge-Chang.
Current Biology. 2016. http://dx.doi.org/10.1016/j.cub.2016.02.031
Estimation statistics should replace significance testing.
Adam Claridge-Chang, Pryseley N. Assam.
Nature Methods. 2016. http://dx.doi.org/10.1038/nmeth.3729
Drosophila learn efficient paths to a food source.
Rapeechai Navawongse, Deepak Choudhury, Marlena Raczkowska, James C Stewart, Terrence Lim, Mashiur Rahman, Alicia Guek Geok Toh, Zhiping Wang, Adam Claridge-Chang.
Neurobiology of Learning and Memory. 2016. doi:10.1016/j.nlm.2016.03.019
Mouse pose estimation from depth images.
Ashwin Nanjappa, Li Cheng, Wei Gao, Chi Xu, Adam Claridge-Chang, Zoe Bichler.
arXiv. 2015. arXiv:1511.07611
Estimating information processing through a memory system: the utility of meta-analytic methods for genetics.
Tugce Yildizoglu, Jan-Marek Weislogel, Farhan Mohammad, Edwin S.-Y. Chan, Pryseley N. Assam, Adam Claridge-Chang.
PLOS Genetics. 2015. doi: 10.1371/journal.pgen.1005718.
Why countries need to invest more in research.
Adam Claridge-Chang (2014) TODAY 9th July 2014.
The right dorsal habenula limits attraction to an odor in zebrafish.
Seetha Krishnan, Ajay S. Mathuru, Caroline Kibat, Mashiur Rahman, Charlotte E. Lupton, James Stewart, Adam Claridge-Chang, Shih-Cheng Yen, Suresh Jesuthasan.
Current Biology (2014), vol 24.
The surveillance state of behavioral automation.
Andreas T Schaefer, Adam Claridge-Chang.
Current Opinion in Neurobiology (2012) 22: 170-176.
Today. Mar 2022
Clearing the air on Covid-19 transmission
The Straits Times. Feb 2022
Most primary olfactory neurons have individually neutral effects on behavior
Tayfun Tumkaya, Safwan Burhanudin, Asghar Khalilnezhad, James Stewart, Hyungwon Choi, Adam Claridge-Chang
eLife 2022. Data available at Zenodo.
China’s ‘zero Covid’ vs Singapore’s ‘living with it’: rapid low-cost testing could mean we don’t need to choose
South China Morning Post. Oct 2021
Contingent stimulus delivery assay for zebrafish reveals a role for CCSER1 in alcohol preference
Fatima Megala Nathan, Caroline Kibat, Tanisha Goel, James Stewart, Adam Claridge-Chang, Ajay S Mathuru
Addiction Biology 2022.
Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host
Benjamin Wong Wei Xiang, Wilfried A. A. Saron, James Charles Stewart, Arthur Hain, Varsha Walvekar, Dorothée Missé, Fréderic Thomas, R. Manjunatha Kini, Benjamin Roche, Adam Claridge-Chang, Ashley L. St John, Julien Pompon
PNAS 2022.
Characterization of seizure induction methods in Drosophila
Jurga Mituzaite, Rasmus Petersen, Adam Claridge-Chang, Richard A. Baines
eNeuro 2021.
A neural m6A/YTHDF pathway is required for learning and memory in Drosophila
Lijuan Kan, Stanislav Ott, Brian Joseph, Eun Sil Park, Crystal Dai, Ralph Kleiner, Adam Claridge-Chang, Eric C. Lai
Nature Communications 2021.
Neurons that function within an integrator to promote a persistent behavioral state in Drosophila
Yonil Jung, Ann Kennedy, Hui Chiu, Farhan Mohammad, Adam Claridge-Chang, David J. Anderson
Neuron 2020.
Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy
Holger Hengel et al. Nature Communications 2019.
Moving beyond P values: Data analysis with estimation plots
Joses Ho, Tayfun Tumkaya, Sameer Aryal, Hyungwon Choi, Adam Claridge-Chang
Nature Methods 2019. (bioRxiv 2018)
- Presents the ideas behind three libraries and a user-friendly web app.
- Preprint first-year downloads 15K. Paper first-month downloads 10K (July 2019).
- Led to a change in statistics policy at the journal eNeuro.
Learning a spatial task by trial and error in Drosophila
Ulrich Stern, Hemant Srivastava, Hsueh-Ling Chen, Farhan Mohammad, Adam Claridge-Chang, Chung-Hui Yang
Current Biology 2019.
Motor context coordinates visually guided walking in Drosophila
Tomás Cruz, Terufumi Fujiwara, Nélia Varela, Farhan Mohammad, Adam Claridge-Chang, M Eugenia Chiappe
bioRxiv. 2019.
Fully automated leg tracking of Drosophila neurodegeneration models reveals distinct conserved movement signatures
Shuang Wu, Kah Junn Tan, Lakshmi Narasimhan Govindarajan, James Charles Stewart, Lin Gu, Joses Wei Hao Ho, Malvika Katarya, Boon Hui Wong, Eng-King Tan, Daiqin Li, Adam Claridge-Chang, Camilo David Libedinsky, Li Cheng, Sherry Shiying Aw
PLOS Biology 2019. (bioRxiv 2018)
Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity
Anders Eriksson, Prachi Anand, Juliette Gorson, Corina Grijuc, Elina Hadelia, James Stewart, Mandë Holford, Adam Claridge-Chang
Scientific Reports. 2018.
- Covered in A*STAR Research.
A systematic review of Drosophila short-term-memory genetics: meta-analysis reveals robust reproducibility
Tayfun Tumkaya, Stanislav Ott, Adam Claridge-Chang
Neuroscience and Biobehavioral Reviews. 2018.
The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors
Joel Selkrig, Farhan Mohammad, Soon Hwee Ng, Jia Yi Chua, Tayfun Tumkaya, Joses Ho, Yin Ning Chiang, Dirk Rieger, Sven Pettersson, Charlotte Helfrich-Foerster, Joanne Yew, Adam Claridge-Chang
Scientific Reports. 2018.
- Covered in A*STAR Research.
- The sleep data are available on Zenodo.
A zinc-finger fusion protein refines Gal4-defined neural circuits
Shamprasad Varija Raghu, Farhan Mohammad, Jia Yi Chua, Claudia Barros, Joanne Lam, Mavis Loberas, Sadhna Sahani, Adam Claridge-Chang
Molecular Brain. 2018.
Optical inhibition of zebrafish behavior with anion channelrhodopsins
Gadisti Aisha Mohamed, Ruey-Kuang Cheng, Joses Ho, Seetha Krishnan, Farhan Mohammad, Adam Claridge-Chang and Suresh Jesuthasan.
BMC Biology. 2017
Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
Anders Eriksson, Marlena Raczkowska, Rapeechai Navawongse, Deepak Choudhury, James Stewart, Yi Ling Tang, Zhiping Wang, Adam Claridge-Chang.
Scientific Reports. 2017.
- Covered in A*STAR Research.
Optogenetic inhibition of behavior with anion channelrhodopsins
Farhan Mohammad, James Stewart, Stanislav Ott, Katarina Chlebikova, Jia Yi Chua, Tong-Wey Koh, Joses Ho, Adam Claridge-Chang.
Nature Methods. 2017. https://doi.org/10.1038/nmeth.4148
- Preprint here.
- Highlighted in A*STAR Research and BioWorld.
- Data available at Zenodo.
Lie-X: Depth image based articulated object pose estimation, tracking, and action recognition on Lie groups
Chi Xu, Lakshmi Narasimhan Govindarajan, Yu Zhang, James Stewart, Zoë Bichler, Suresh Jesuthasan, Adam Claridge-Chang, Ajay Sriram Mathuru, Wenlong Tang, Peixin Zhu, Li Cheng.
International Journal of Computer Vision. 2017.
Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses.
Farhan Mohammad, Joses Ho, Chun Lei Lim, Jia Hern Woo, Dennis Jun Jie Poon, Bhumika Lamba, Adam Claridge-Chang.
Neuroscience & Biobehavioral Reviews. 2016. doi:10.1016/j.neubiorev.2016.04.011
- Highlighted by Microscope blog.
Ancient anxiety pathways influence Drosophila defense behaviors.
Farhan Mohammad, Sameer Aryal, Joses Ho, James Charles Stewart, Nurul Ayuni Norman, Teng Li Tan, Agnese Eisaka, Adam Claridge-Chang.
Current Biology. 2016. http://dx.doi.org/10.1016/j.cub.2016.02.031
- Highlighted in Medical Daily, Asian Scientist, Science Daily, Trends der Zukunft.
Estimation statistics should replace significance testing.
Adam Claridge-Chang, Pryseley N. Assam.
Nature Methods. 2016. http://dx.doi.org/10.1038/nmeth.3729
- Full text here.
Drosophila learn efficient paths to a food source.
Rapeechai Navawongse, Deepak Choudhury, Marlena Raczkowska, James C Stewart, Terrence Lim, Mashiur Rahman, Alicia Guek Geok Toh, Zhiping Wang, Adam Claridge-Chang.
Neurobiology of Learning and Memory. 2016. doi:10.1016/j.nlm.2016.03.019
Mouse pose estimation from depth images.
Ashwin Nanjappa, Li Cheng, Wei Gao, Chi Xu, Adam Claridge-Chang, Zoe Bichler.
arXiv. 2015. arXiv:1511.07611
Estimating information processing through a memory system: the utility of meta-analytic methods for genetics.
Tugce Yildizoglu, Jan-Marek Weislogel, Farhan Mohammad, Edwin S.-Y. Chan, Pryseley N. Assam, Adam Claridge-Chang.
PLOS Genetics. 2015. doi: 10.1371/journal.pgen.1005718.
- Highlighted by A*STAR Research.
Why countries need to invest more in research.
Adam Claridge-Chang (2014) TODAY 9th July 2014.
The right dorsal habenula limits attraction to an odor in zebrafish.
Seetha Krishnan, Ajay S. Mathuru, Caroline Kibat, Mashiur Rahman, Charlotte E. Lupton, James Stewart, Adam Claridge-Chang, Shih-Cheng Yen, Suresh Jesuthasan.
Current Biology (2014), vol 24.
The surveillance state of behavioral automation.
Andreas T Schaefer, Adam Claridge-Chang.
Current Opinion in Neurobiology (2012) 22: 170-176.
Before lab formation
Writing memories with light-addressable reinforcement circuitry.
A Claridge-Chang, R Roorda, E Vrontou, L Sjulson, H Li, J Hirsh, G Miesenböck.
(2009) Cell 139: 405-415.
Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe.
Y Shang, A Claridge-Chang, L Sjulson, M Pypaert, G Miesenböck. (2007)
Cell 128: 601-612
Control of daily transcript oscillations in Drosophila by light and the circadian clock.
H Wijnen, F Naef, C Boothroyd, A Claridge-Chang, MW Young. (2006)
PLoS Genetics 2: e39.
Molecular genetics of timing in intrinsic circadian rhythm sleep disorders.
H Wijnen, C Boothroyd, MW Young, A Claridge-Chang. (2002)
Annals of Medicine 34: 386-393.
Circadian regulation of gene expression systems in the Drosophila head.
A Claridge-Chang, H Wijnen, F Naef, C Boothroyd, N Rajewsky, MW Young. (2001)
Neuron 32: 657-671.
Writing memories with light-addressable reinforcement circuitry.
A Claridge-Chang, R Roorda, E Vrontou, L Sjulson, H Li, J Hirsh, G Miesenböck.
(2009) Cell 139: 405-415.
- Highlighted in Nature News, Science Now, New Scientist, CBC, BBC News, Wired, New York Times, Folha da S. Paulo and others.
- Highlighted in T Dean and A Sehgal. (2009) New routes for memory retrieval and reinforcement. Cell 139: 225-7
Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe.
Y Shang, A Claridge-Chang, L Sjulson, M Pypaert, G Miesenböck. (2007)
Cell 128: 601-612
- Highlighted in B Leung and S Waddell. (2007) Smelling Excitement in the Antennal Lobe. Cell 128: 431-2.]
Control of daily transcript oscillations in Drosophila by light and the circadian clock.
H Wijnen, F Naef, C Boothroyd, A Claridge-Chang, MW Young. (2006)
PLoS Genetics 2: e39.
Molecular genetics of timing in intrinsic circadian rhythm sleep disorders.
H Wijnen, C Boothroyd, MW Young, A Claridge-Chang. (2002)
Annals of Medicine 34: 386-393.
Circadian regulation of gene expression systems in the Drosophila head.
A Claridge-Chang, H Wijnen, F Naef, C Boothroyd, N Rajewsky, MW Young. (2001)
Neuron 32: 657-671.
- Highlighted in FR Jackson, AJ Schroeder (2001) A Timely Expression Profile. Developmental Cell 1: 730-731.